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studies were performed using carrageenin-induced pleurisy in rats pre-treated with PACs.
Cell-cell and cell-extracellular matrix interactions play a central role in cell migration and leukocyte activation during the inflammatory process.
Leukocyte cell adhesion molecules mobilization was not down-regulated on granulocytes by PACs.
Immunohistochemistry on lung sections showed a decreased production of endothelial cell adhesion molecules.
Here we report the identification of an 11-k Da synthetic protein, M5, that binds to human ICAM-1 and ICAM-4, as shown by in vitro interaction studies, surface plasmon resonance and immunolocalization.
M5 greatly inhibits the invasion of macrophages and erythrocytes by Mycobacterium tuberculosis and Plasmodium falciparum, respectively. falciparum merozoites, and the addition of recombinant ICAM-4 to parasite cultures blocks invasion of erythrocytes by newly released merozoites.